Efficacy of daily intake of Lactobacillus casei Shirota on respiratory symptoms and influenza vaccination immune response: a randomized, double-blind, placebo-controlled trial in healthy elderly nursing home residents.
Identifieur interne : 000055 ( Main/Exploration ); précédent : 000054; suivant : 000056Efficacy of daily intake of Lactobacillus casei Shirota on respiratory symptoms and influenza vaccination immune response: a randomized, double-blind, placebo-controlled trial in healthy elderly nursing home residents.
Auteurs : Karolien Van Puyenbroeck [Belgique] ; Niel Hens ; Samuel Coenen ; Barbara Michiels ; Caroline Beunckens ; Geert Molenberghs ; Paul Van Royen ; Veronique VerhoevenSource :
- The American journal of clinical nutrition [ 1938-3207 ] ; 2012.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Analyse multivariée, Animaux, Anticorps (sang), Belgique, Femelle, Fermentation, Humains, Lactobacillus casei, Lait (microbiologie), Maisons de repos, Modèles logistiques, Mâle, Méthode en double aveugle, Probiotiques (administration et posologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Tests d'inhibition de l'hémagglutination, Vaccination, Vaccins antigrippaux (immunologie).
- MESH :
- administration et posologie : Probiotiques.
- immunologie : Vaccins antigrippaux.
- microbiologie : Lait.
- sang : Anticorps.
- Adulte d'âge moyen, Analyse multivariée, Animaux, Belgique, Femelle, Fermentation, Humains, Lactobacillus casei, Maisons de repos, Modèles logistiques, Mâle, Méthode en double aveugle, Sujet âgé, Sujet âgé de 80 ans ou plus, Tests d'inhibition de l'hémagglutination, Vaccination.
- Wicri :
- geographic : Belgique.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Animals, Antibodies (blood), Belgium, Double-Blind Method, Female, Fermentation, Hemagglutination Inhibition Tests, Humans, Influenza Vaccines (immunology), Lactobacillus casei, Logistic Models, Male, Middle Aged, Milk (microbiology), Multivariate Analysis, Nursing Homes, Probiotics (administration & dosage), Vaccination.
- MESH :
- chemical , blood : Antibodies.
- chemical , immunology : Influenza Vaccines.
- geographic : Belgium.
- administration & dosage : Probiotics.
- microbiology : Milk.
- Aged, Aged, 80 and over, Animals, Double-Blind Method, Female, Fermentation, Hemagglutination Inhibition Tests, Humans, Lactobacillus casei, Logistic Models, Male, Middle Aged, Multivariate Analysis, Nursing Homes, Vaccination.
Abstract
BACKGROUND
Age is associated with immune dysregulation, which results in an increased infection rate and reduced effectiveness of vaccination.
OBJECTIVE
We assessed whether an intervention with Lactobacillus casei Shirota (LcS) in elderly nursing home residents reduced their susceptibility to respiratory symptoms and improved their immune response to influenza vaccination.
DESIGN
Between October 2007 and April 2008, a randomized, double-blind, placebo-controlled trial was conducted in 737 healthy people aged ≥ 65 y in 53 nursing homes in Antwerp, Belgium. Volunteers were randomly assigned to receive a probiotic (n = 375; 2 bottles of fermented milk that contained ≥ 6.5 × 10(9) live LcS/bottle) or a placebo (n = 362; similar drink with no bacteria) for 176 d. After 21 d, all subjects received an influenza vaccination. Primary outcome parameters were the number of days with respiratory symptoms, the probability of respiratory symptoms, and antiinfluenza antibody titer by hemagglutination inhibition after vaccination.
RESULTS
Univariate and multivariate modeling showed no effect of the probiotic on clinical outcome parameters. Generalized linear mixed modeling showed no effect of the probiotic itself on the probability of respiratory symptoms [OR of probiotic: 0.8715; 95% CI: 0.6168, 1.2887). No significant difference regarding the influenza-vaccination immune response was shown.
CONCLUSION
The results of this study show that daily consumption of a fermented milk drink that contains LcS has no statistically or clinically significant effect on the protection against respiratory symptoms. This trial was registered at clinicaltrials.gov as NCT00849277.
DOI: 10.3945/ajcn.111.026831
PubMed: 22440853
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Hens, Niel" sort="Hens, Niel" uniqKey="Hens N" first="Niel" last="Hens">Niel Hens</name></author><author><name sortKey="Coenen, Samuel" sort="Coenen, Samuel" uniqKey="Coenen S" first="Samuel" last="Coenen">Samuel Coenen</name></author><author><name sortKey="Michiels, Barbara" sort="Michiels, Barbara" uniqKey="Michiels B" first="Barbara" last="Michiels">Barbara Michiels</name></author><author><name sortKey="Beunckens, Caroline" sort="Beunckens, Caroline" uniqKey="Beunckens C" first="Caroline" last="Beunckens">Caroline Beunckens</name></author><author><name sortKey="Molenberghs, Geert" sort="Molenberghs, Geert" uniqKey="Molenberghs G" first="Geert" last="Molenberghs">Geert Molenberghs</name></author><author><name sortKey="Van Royen, Paul" sort="Van Royen, Paul" uniqKey="Van Royen P" first="Paul" last="Van Royen">Paul Van Royen</name></author><author><name sortKey="Verhoeven, Veronique" 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sortKey="Van Puyenbroeck, Karolien" sort="Van Puyenbroeck, Karolien" uniqKey="Van Puyenbroeck K" first="Karolien" last="Van Puyenbroeck">Karolien Van Puyenbroeck</name><affiliation wicri:level="4"><nlm:affiliation>Department of Primary and Interdisciplinary Care, University of Antwerp, Antwerp, Belgium. karolien.vanpuyenbroeck@ua.ac.be</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Primary and Interdisciplinary Care, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Hens, Niel" sort="Hens, Niel" uniqKey="Hens N" first="Niel" last="Hens">Niel Hens</name></author><author><name sortKey="Coenen, Samuel" sort="Coenen, Samuel" uniqKey="Coenen S" first="Samuel" last="Coenen">Samuel Coenen</name></author><author><name sortKey="Michiels, Barbara" sort="Michiels, Barbara" uniqKey="Michiels B" first="Barbara" last="Michiels">Barbara Michiels</name></author><author><name sortKey="Beunckens, Caroline" sort="Beunckens, Caroline" uniqKey="Beunckens C" first="Caroline" last="Beunckens">Caroline Beunckens</name></author><author><name sortKey="Molenberghs, Geert" sort="Molenberghs, Geert" uniqKey="Molenberghs G" first="Geert" last="Molenberghs">Geert Molenberghs</name></author><author><name sortKey="Van Royen, Paul" sort="Van Royen, Paul" uniqKey="Van Royen P" first="Paul" last="Van Royen">Paul Van Royen</name></author><author><name sortKey="Verhoeven, Veronique" sort="Verhoeven, Veronique" uniqKey="Verhoeven V" first="Veronique" last="Verhoeven">Veronique Verhoeven</name></author></analytic><series><title level="j">The American journal of clinical nutrition</title><idno type="eISSN">1938-3207</idno><imprint><date when="2012" 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casei</term><term>Lait (microbiologie)</term><term>Maisons de repos</term><term>Modèles logistiques</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Probiotiques (administration et posologie)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tests d'inhibition de l'hémagglutination</term><term>Vaccination</term><term>Vaccins antigrippaux (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Belgium</term></keywords><keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Probiotics</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Probiotiques</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Lait</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Milk</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Double-Blind Method</term><term>Female</term><term>Fermentation</term><term>Hemagglutination Inhibition Tests</term><term>Humans</term><term>Lactobacillus casei</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Nursing Homes</term><term>Vaccination</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse multivariée</term><term>Animaux</term><term>Belgique</term><term>Femelle</term><term>Fermentation</term><term>Humains</term><term>Lactobacillus casei</term><term>Maisons de repos</term><term>Modèles logistiques</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tests d'inhibition de l'hémagglutination</term><term>Vaccination</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Belgique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Age is associated with immune dysregulation, which results in an increased infection rate and reduced effectiveness of vaccination.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>We assessed whether an intervention with Lactobacillus casei Shirota (LcS) in elderly nursing home residents reduced their susceptibility to respiratory symptoms and improved their immune response to influenza vaccination.</p></div><div type="abstract" xml:lang="en"><p><b>DESIGN</b></p><p>Between October 2007 and April 2008, a randomized, double-blind, placebo-controlled trial was conducted in 737 healthy people aged ≥ 65 y in 53 nursing homes in Antwerp, Belgium. Volunteers were randomly assigned to receive a probiotic (n = 375; 2 bottles of fermented milk that contained ≥ 6.5 × 10(9) live LcS/bottle) or a placebo (n = 362; similar drink with no bacteria) for 176 d. After 21 d, all subjects received an influenza vaccination. Primary outcome parameters were the number of days with respiratory symptoms, the probability of respiratory symptoms, and antiinfluenza antibody titer by hemagglutination inhibition after vaccination.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Univariate and multivariate modeling showed no effect of the probiotic on clinical outcome parameters. Generalized linear mixed modeling showed no effect of the probiotic itself on the probability of respiratory symptoms [OR of probiotic: 0.8715; 95% CI: 0.6168, 1.2887). No significant difference regarding the influenza-vaccination immune response was shown.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>The results of this study show that daily consumption of a fermented milk drink that contains LcS has no statistically or clinically significant effect on the protection against respiratory symptoms. This trial was registered at clinicaltrials.gov as NCT00849277.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22440853</PMID><DateCompleted><Year>2012</Year><Month>06</Month><Day>14</Day></DateCompleted><DateRevised><Year>2012</Year><Month>04</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1938-3207</ISSN><JournalIssue CitedMedium="Internet"><Volume>95</Volume><Issue>5</Issue><PubDate><Year>2012</Year><Month>May</Month></PubDate></JournalIssue><Title>The American journal of clinical nutrition</Title><ISOAbbreviation>Am. J. Clin. Nutr.</ISOAbbreviation></Journal><ArticleTitle>Efficacy of daily intake of Lactobacillus casei Shirota on respiratory symptoms and influenza vaccination immune response: a randomized, double-blind, placebo-controlled trial in healthy elderly nursing home residents.</ArticleTitle><Pagination><MedlinePgn>1165-71</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3945/ajcn.111.026831</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Age is associated with immune dysregulation, which results in an increased infection rate and reduced effectiveness of vaccination.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We assessed whether an intervention with Lactobacillus casei Shirota (LcS) in elderly nursing home residents reduced their susceptibility to respiratory symptoms and improved their immune response to influenza vaccination.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Between October 2007 and April 2008, a randomized, double-blind, placebo-controlled trial was conducted in 737 healthy people aged ≥ 65 y in 53 nursing homes in Antwerp, Belgium. Volunteers were randomly assigned to receive a probiotic (n = 375; 2 bottles of fermented milk that contained ≥ 6.5 × 10(9) live LcS/bottle) or a placebo (n = 362; similar drink with no bacteria) for 176 d. After 21 d, all subjects received an influenza vaccination. Primary outcome parameters were the number of days with respiratory symptoms, the probability of respiratory symptoms, and antiinfluenza antibody titer by hemagglutination inhibition after vaccination.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Univariate and multivariate modeling showed no effect of the probiotic on clinical outcome parameters. Generalized linear mixed modeling showed no effect of the probiotic itself on the probability of respiratory symptoms [OR of probiotic: 0.8715; 95% CI: 0.6168, 1.2887). No significant difference regarding the influenza-vaccination immune response was shown.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The results of this study show that daily consumption of a fermented milk drink that contains LcS has no statistically or clinically significant effect on the protection against respiratory symptoms. 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Royen</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Verhoeven</LastName><ForeName>Veronique</ForeName><Initials>V</Initials></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT00849277</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>03</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Clin 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Type="Geographic">Belgium</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005285" MajorTopicYN="N">Fermentation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006385" MajorTopicYN="N">Hemagglutination Inhibition Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007780" MajorTopicYN="Y">Lactobacillus casei</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic 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PubStatus="entrez"><Year>2012</Year><Month>3</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>3</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>6</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22440853</ArticleId><ArticleId IdType="pii">ajcn.111.026831</ArticleId><ArticleId IdType="doi">10.3945/ajcn.111.026831</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Belgique</li></country><region><li>Province d'Anvers</li><li>Région flamande</li></region><settlement><li>Anvers</li></settlement><orgName><li>Université d'Anvers</li></orgName></list><tree><noCountry><name sortKey="Beunckens, Caroline" sort="Beunckens, Caroline" uniqKey="Beunckens C" first="Caroline" last="Beunckens">Caroline Beunckens</name><name sortKey="Coenen, Samuel" sort="Coenen, Samuel" uniqKey="Coenen S" first="Samuel" last="Coenen">Samuel Coenen</name><name sortKey="Hens, Niel" sort="Hens, Niel" uniqKey="Hens N" first="Niel" last="Hens">Niel Hens</name><name sortKey="Michiels, Barbara" sort="Michiels, Barbara" uniqKey="Michiels B" first="Barbara" last="Michiels">Barbara Michiels</name><name sortKey="Molenberghs, Geert" sort="Molenberghs, Geert" uniqKey="Molenberghs G" first="Geert" last="Molenberghs">Geert Molenberghs</name><name sortKey="Van Royen, Paul" sort="Van Royen, Paul" uniqKey="Van Royen P" first="Paul" last="Van Royen">Paul Van Royen</name><name sortKey="Verhoeven, Veronique" sort="Verhoeven, Veronique" uniqKey="Verhoeven V" first="Veronique" last="Verhoeven">Veronique Verhoeven</name></noCountry><country name="Belgique"><region name="Région flamande"><name sortKey="Van Puyenbroeck, Karolien" sort="Van Puyenbroeck, Karolien" uniqKey="Van Puyenbroeck K" first="Karolien" last="Van Puyenbroeck">Karolien Van Puyenbroeck</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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